Endocrine Abstracts

Objectives: The brain plays a major role in controlling the desire to eat. We performed a meta-analysis to assess the association of dopamine transporter (DAT)/dopamine receptor (DR) availabilities from neuroimaging studies with obesity.Methods: We performed a systematic search of MEDLINE and EMBASE for English-language publications. Data were extracted from the publications independently by two reviewers. Effect sizes were correlation coefficient betwee...

Objective: Thyroid dysfunction is frequently associated with functional disturbances of the brain. We performed a meta-analysis of previous positron emission tomography and single-photon emission computed tomography studies using a coordinate-based technique of activation-likelihood estimation (ALE) to investigate the potential background of neuropsychiatric complications in patients with hypo- and hyperthyroidism.Methods: We performed a systematic searc...

Objectives: Attempts have been made to identify markers for aggressive disease in papillary microcarcinomas (PMCs), but genetic alterations identified in PMCs have failed to distinguish tumors with high-risk features. Thus, we aimed to identify candidate markers associated with lateral node metastasis (N1b) in patients with PMC through a transcriptomic analysis.Methods: Bulk RNA sequencing was performed in 26 matched tumor and normal thyroid tissue sampl...

Purpose: The purpose of this study was to evaluate the prevalence and characteristics of individuals with spine–femur bone mineral density (BMD) discordance and to examine whether trabecular bone score (TBS) is associated with major and minor BMD discordance in postmenopausal women.Methods: This retrospective study included 533 healthy postmenopausal women (median age, 60 years; range, 55–82 years) who visited our hospital for a health check-up...

Background: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.Methods: This historical cohort study included 357 pat...

Background: Recent studies presented that younger patients with papillary thyroid microcarcinoma (PTMC) had poorer clinical outcomes compared to older PTMC patients. The aim of this study is to investigate the impact of patient’s age on the lymph node metastasis (LNM) status of PTMC, a risk factor for recurrence and poor clinical outcome of PTMC.Methods: The study evaluated 2068 PTMC patients who underwent thyroid operation with lymph node (LN) diss...

Background: The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Aim of this study was to evaluate the ability of serum calcitonin and carcinoembryonic antigen(CEA) to predict the extent of surgery needed in the lateral neck in patients with MTC.Methods: This retrospective multicenter cohort study included data from patients with MTC surgically treated in the 6 tertiary medical centers in Korea from 1996 to 202...